Nerve Growth Factor (NGF) Encourages the Neuroinvasive Potential of Pancreatic Cancer Cells by Activating the Warburg Effect and Promoting Tumor Derived Exosomal miRNA-21 Expression

<div>NGF/TrkA activated the PI3K/AKT/mTOR signaling pathway and enhanced the interaction between PC cells and DRG cells. (a)Western blotting was employed to test the levels of PI3K, p-AKT, and p-mTOR in MiaPaCa-2 cells treated with 100 ng/ml of NGF or/and transfected with TrkA siRNA for 48 h. (b-e) Transwell was used to detect migration and invasion of DGR or MiaPaCa-2 cells treated with 100 ng/ml of NGF or/and transfected with TrkA siRNA for 48 h. (f) Schematic of MiaPaCa-2 and DGR invasion. (g) DRG growth index. 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Nerve Growth Factor (NGF) Encourages the Neuroinvasive Potential of Pancreatic Cancer Cells by Activating the Warburg Effect and Promoting Tumor Derived Exosomal miRNA-21 Expression 

Figure 4 | Nerve Growth Factor (NGF) Encourages the Neuroinvasive Potential of Pancreatic Cancer Cells by Activating the Warburg Effect and Promoting Tumor Derived Exosomal miRNA-21 Expression 