Neonatal Oxidative Stress Impairs Cortical Synapse Formation and GABA Homeostasis in Parvalbumin-Expressing Interneurons

Figure 1

Oxidative stress in the immature cortex of mice exposed to neonatal hyperoxia. Schematic overview of oxidative stress exposure (a). Five-day-old mouse pups were exposed to 80% oxygen for 48 hours and kept at room air conditions (21% oxygen) thereafter. Western blot analysis of nitrotyrosine reveals increased oxidative stress-induced protein nitration after exposure to neonatal hyperoxia at P7 (b) (, -test ).

(a)

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