Neonatal Oxidative Stress Impairs Cortical Synapse Formation and GABA Homeostasis in Parvalbumin-Expressing Interneurons

Figure 3

Maturation of cortical GABAergic interneurons. GABA receptor alpha subunit distribution indicates maturational state of GABAergic interneurons. Gabra3 and Gabra5 expression indicates immature state. Gabra1 and Gabra4 expression indicates mature state. AT P7, P9, P11, P14, and P30, qPCR analysis of Gabra1 (a), Gabra3 (b), Gabra4 (c), and Gabra5 (d) did not indicate maturational differences of GABAergic interneurons. However, at P30 RNA, expression of Gabra5 was increased in cortical samples of mice previously exposed to hyperoxia (-8, -test ).

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