Pioglitazone Hydrochloride Extends the Lifespan of Caenorhabditis elegans by Activating DAF-16/FOXO- and SKN-1/NRF2-Related Signaling Pathways

Figure 1

PGZ extends the lifespan of C. elegans. (a) Chemical structure of PGZ. (b) Survival curves of wild-type N2 worms exposed to increasing concentrations of PGZ (0.1-2 mM). (c) Dose-dependent analyses of the effect of PGZ on the lifespan of C. elegans. Error bars represent the SD. of the percentage of lifespan extension from independent experiments (; , , and NS (not significant); Student’s -test). Lifespan was calculated with the Kaplan-Meier test, and values were calculated using the log-rank test. Experiments were repeated at least twice, and detailed lifespan values were summarized in Supplementary Table S1. (d) Age-related movements of worms treated with 0.5 mM PGZ and those of untreated controls (; ; ; Student’s -test).

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