Pioglitazone Hydrochloride Extends the Lifespan of Caenorhabditis elegans by Activating DAF-16/FOXO- and SKN-1/NRF2-Related Signaling Pathways

Figure 4

PGZ-induced lifespan extension depends on its regulation of DR-like and reproductive signaling pathways. (a–d) Survival analyses of aak-2(ok524) (a), eat-2(ad1116) (b), glp-1(e2144) (c), and daf-12(rh61rh411) (d) mutants treated with or without 0.5 mM PGZ ( value by the log-rank test). The lifespan values of the repeat experiments were summarized in Supplementary Table S1. (e) mRNA expression levels of daf-12 target genes (fard-1, lips-17, and cdr-6) (; independent experiments; and ; Student’s -test).

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