The Role of Oxidative Stress in the Pathogenesis of Vitiligo: A Culprit for Melanocyte Death

Figure 1

Crosstalk between autophagy and Nrf2 pathway under oxidative stress. When Nrf2 pathway is activated following exposure to excess ROS, or autophagy dysregulation, Nrf2 translocates to the nucleus and binds the ARE to activate the transcription of its target genes. Examples of the general processes regulated by Nrf2 target pathways are indicated. ROS: reactive oxygen species; ER: endoplasmic reticulum.