Dl-3-n-Butylphthalide Improves Neuroinflammation in Mice with Repeated Cerebral Ischemia-Reperfusion Injury through the Nrf2-Mediated Antioxidant Response and TLR4/MyD88/NF-κB Signaling Pathway

Figure 10

Scheme summarizing the proposed mechanisms for the antioxidant, antineuroinflammatory, and neuroprotective effects of NBP in RCIR-stimulated VD mice. Mechanisms involve the promotion of antioxidant enzyme expression, reduction of PICs, inhibition of TLR4/MyD88/NF-κB signaling and microglial proliferation, and the key role of NBP-mediated Nrf2 activation in the process.