Dl-3-n-Butylphthalide Improves Neuroinflammation in Mice with Repeated Cerebral Ischemia-Reperfusion Injury through the Nrf2-Mediated Antioxidant Response and TLR4/MyD88/NF-κB Signaling Pathway

Figure 9

The neuroprotective effects of NBP were abolished in Nrf2^-/- mice. (a)–(c) Quantification of time latency, swimming speed, and the percentage of time spent in the target quadrant was measured in WT and Nrf2^-/- mice using MWM. per group. (d)–(f) Representative images of HE staining (400×, ), the ultrastructure of neurons (), and TUNEL staining (400×, ) in the hippocampal CA1 region. (g) The quantitative graph for TUNEL staining of the hippocampus. or 4 per group. (h)–(j) Western blot analysis of Bax and Bcl-2 expression. per group. β-Actin was used as an internal control. ^##, ^###, the vs. the group; ns: not significant, as indicated. Values are expressed as .

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