Research Article
Melatonin Alleviates PM2.5-Induced Hepatic Steatosis and Metabolic-Associated Fatty Liver Disease in ApoE-/- Mice
Figure 3
Melatonin ameliorated abnormal liver lipid metabolism caused by elevated PTP1B expression induced by PM2.5. (a) The mRNA expression of PTP1B, PP2A, SP1, and SREBP-1. (b) Western blotting of PTP1B, PP2A, P-PP2A, SP1, P-SP1, and SREBP-1. (c) Protein quantification of PTP1B. (d) Protein quantification of P-PP2A/PP2A. (e) Protein quantification of P-SP1/SP1. (f) Protein quantification of SREBP-1. (g) The activity of PP2A. (h) The activity of SP1. All values are presented as the (). for Con group vs PM2.5 group and # for PM2.5 group vs PM2.5+Mel group.
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