Treadmill Training Reduces Cerebral Ischemia-Reperfusion Injury by Inhibiting Ferroptosis through Activation of SLC7A11/GPX4

Figure 1

Treadmill training attenuated the neurological deficit in cerebral I/R (ischemia/reperfusion) injury-operated rats. (a) Representative 2-D laser speckle images of MCAO rat. (b) Real-time monitoring of blood flow in left and right cerebral cortex of MCAO rats. (c) Compared with the sham operation group, the neurological deficit score in the MCAO group was significantly higher. After exercise training, the neurological deficit score in the treadmill training group was significantly lower ( for sham, MCAO, and MCAO + Treadmill rats). (d) Compared with the sham operation group, the grasping power in the MCAO group was significantly lower. After exercise training, the grasping power was significantly higher ( for sham, MCAO, and MCAO + Treadmill rats). vs. sham; ^# vs. MCAO; ^#### vs. MCAO.

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