Research Article
Treadmill Training Reduces Cerebral Ischemia-Reperfusion Injury by Inhibiting Ferroptosis through Activation of SLC7A11/GPX4
Figure 5
Erastin-induced ferroptosis reverses the antilipid peroxidation effect of treadmill training. (a–d) The effects of erastin on activities of GSH-PX and levels of GSH, MDA, and iron from different groups, respectively. Treadmill training could inhibit the lipid peroxidation induced by cerebral I/R. However, when SLC7A11 was inhibited, treadmill training inhibiting ferroptosis effects could be partially repealed. vs. sham; vs. sham; # vs. MCAO; ## vs. MCAO; & vs. MCAO + Treadmill.
(a) |
(b) |
(c) |
(d) |