Inhibition of PFKFB Preserves Intestinal Barrier Function in Sepsis by Inhibiting NLRP3/GSDMD

Figure 2

Inhibition of PFKFB3 and Gsdmd gene knockout can improve the prognosis of septic mice. (a) The coexpression of PFKFB3 and GSDMD was analyzed by MEM. (b, c) The LPS-induced PFKFB3 expression was inhibited by 3PO in Caco-2 cells. (d) GSDMD and GSDMD-NT expression in intestinal tissues of wild-type and Gsdmd^-/- mice after sham or CLP operation. (e) Survival rates were calculated in different groups. The values were shown as ( per group in (d) and (e)). Statistical analysis was performed using a -test (e) and log-rank test (c). versus sham group; ^#, ^##, and ^### versus CLP group.

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