Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying circ_0050205 Attenuate Intervertebral Disc Degeneration

Figure 8

The mechanism graph of the regulatory network and function of circ_0050205. BMSC-EVs transferred circ_0050205 to NPCs where circ_0050205 acted as miR-665 sponge and upregulated the expression of the miR-665 target GPX4, thus accelerating NPC survival and reducing ECM degradation, ultimately preventing the IDD.