Tetrahydrofolate Alleviates the Inhibitory Effect of Oxidative Stress on Neural Stem Cell Proliferation through PTEN/Akt/mTOR Pathway

Figure 9

PTEN/Akt/mTOR signaling pathway played an evident role in THF mitigating the reduced NSC proliferation ability initiated by oxidative stress. (a) Immunoblot bands illustrating the expression of p-Akt and Akt in different groups. (b) Semiquantitative analysis of p-Akt/Akt from (a). , , vs. scramble group; ^#, ^## vs. scramble + H₂O₂ group. (c) Bands demonstrating the expression of p-mTOR and mTOR in each group. (d) Semiquantification of p-mTOR/mTOR from (c). , , vs. scramble group; ^#, ^## vs. scramble + H₂O₂ group.

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