Research Article
Downregulation of SIRT3 Aggravates Lung Ischemia Reperfusion Injury by Increasing Mitochondrial Fission and Oxidative Stress through HIF-1α-Dependent Mechanisms
Figure 3
Inhibition of SIRT3 increased mitochondrial oxidative stress, but decreased ATP and MMP after lung I/R in vivo. (a–c) MDA, SOD2, and GSH levels in lung tissues, respectively. (d) The amount of ATP. The data are expressed as ( for panels a, b, c, d), *. (e, f) MitoSOX fluorescence staining and its fluorescence intensity ( per group). (g) Images showing the change in MMP ( per group).
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