Downregulation of SIRT3 Aggravates Lung Ischemia Reperfusion Injury by Increasing Mitochondrial Fission and Oxidative Stress through HIF-1<i>α</i>-Dependent Mechanisms

<div>Knockdown SIRT3 increased the levels of Drp-1 and Fis-1 by regulating HIF-1<i>α</i> after H/R <i>in vitro</i>. (a) Drp-1 and Fis-1 protein levels determined by western blotting. (b, c) Expression of Drp-1 and Fis-1 proteins relative to <i>β</i>-actin. 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Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: Downregulation of SIRT3 Aggravates Lung Ischemia Reperfusion Injury by Increasing Mitochondrial Fission and Oxidative Stress through HIF-1<i>α</i>-Dependent Mechanisms 

Figure 7 | Downregulation of SIRT3 Aggravates Lung Ischemia Reperfusion Injury by Increasing Mitochondrial Fission and Oxidative Stress through HIF-1α-Dependent Mechanisms 