Activation of SIRT1 Alleviates Ferroptosis in the Early Brain Injury after Subarachnoid Hemorrhage

Figure 6

SRIT1 inhibition by SEL aggravated ferroptosis following SAH in vivo and in vitro. (a) Western blotting assay for SIRT1, XCT, GPX4, and FSP1 expression in different groups in vivo. (b–e) Quantification of the expression of SIRT1, XCT, GPX4, and FSP1. (f) Quantitative analysis of MDA in different groups in vivo. (g) Western blotting assay for SIRT1, XCT, GPX4, and FSP1 expression in different groups in vitro. (h–k) Quantification of the expression of SIRT1, XCT, GPX4, and FSP1. (l) Quantitative analysis of MDA. /group. Bars represent the . and . SEL: selisistat; GPX4: glutathione peroxidase 4; FSP1: ferroptosis suppressor protein 1; MDA: malondialdehyde.

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