Senotherapy Protects against Cisplatin-Induced Ovarian Injury by Removing Senescent Cells and Alleviating DNA Damage

Figure 2

Metformin or DQ alone or in combination with each other alleviated the senescent stress induced by cisplatin in vivo. (a) Flowchart of drug administration animal experiment. (b, c) Light microscopic images of SA-β-gal staining and P16^link4a, P21^WAF1/Cip1, and IL-6 IHC staining after different medications. Scar bars are marked on respective images ( =3). (d–g) Quantitative analysis of SA-β-gal–positive area and P16^link4a-, P21^WAF1/Cip1-, and IL-6-postive IOD ( =3). Results are presented using mean ± standard deviation values. , , .

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