MiR-9-5p Inhibits the MMP⁺-Induced Neuron Apoptosis through Regulating SCRIB/β-Catenin Signaling in Parkinson’s Disease

Figure 3

mmu-miR-9-5p regulates the SCRIB/β-catenin signaling pathway by directly targeting SCRIB. Western blot was used to detect possible signals for apoptosis. (a, b, d) p-AKT and β-catenin were upregulated (). (a, c, e, f) p-p38, p-JNK, and p-p65 were downregulated (). (g) The expression of SCRIB mRNA was upregulated in the mmp⁺ group than the control group () and was inhibit by mmu-miR-9-5p () (h, i) The expression of SCRIB was downregulated in the mmu-miR-9-5p group () detected by Western blot. (j) Predicted binding sites of mmu-miR-9-5p and SCRIB. (k) Luciferase reporter assay suggests SCRIB is the direct binding to mmu-miR-9-5p ().

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