Bioinformatic Analysis of Genetic Factors from Human Blood Samples and Postmortem Brains in Parkinson’s Disease

Figure 5

The PPI network reveals interacting proteins. (a) The STRING web program created a PPI network for the genes in DEGs. There were 600 protein-protein interactions in total. (b) Heat map displayed the 50 genes that showed clear alterations in PD. (c) Heat map shows the expression of inflammation-related genes in PD and control groups. (d) Relative gene expression of CCL16, GPR68, FPR3, IL10, SLC11A1, IL15, and LYZ increased significantly in PD compared with the control group. Data are shown as . (e) The STRING web program created a PPI network for the inflammation-related genes. (f) The STRING web program created a PPI network for the hub genes to show the interaction between the proteins. (g) The relative hub genes levels of ACO2, MDH2, SDHA, ATP5A1, UQCRC2, PDHB, SUCLG1, NDUFS3, UQCRC1, and ATP5C1 in PD and control group. (h) Pearson correlation coefficients among individual 10 hub genes. (i) The relative expression of top 3 hub genes ACO2, MDH2, and UQCRC1 in PD and control group.

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