Oxidative Medicine and Cellular Longevity

Research Article

Bioinformatic Analysis of Genetic Factors from Human Blood Samples and Postmortem Brains in Parkinson’s Disease

Table 3

Top 20 clusters with their enriched representative terms (one per cluster). “Count” is the number of genes in the user-provided lists with membership in the given ontology term. “%” is the percentage of all of the user-provided genes that are found in the given ontology term (only input genes with at least one ontology term annotation are included in the calculation). “Log10()” is the value in log base 10. “Log10()” is the multitest adjusted value in log base 10.


GO	Category	Description	Count	%	Log10()	Log10()

GO:0006091	GO biological processes	Generation of precursor metabolites and energy	111	11.92	-62.71	-58.36
hsa01200	KEGG pathway	Carbon metabolism	62	6.66	-62.25	-58.36
GO:0032787	GO biological processes	Monocarboxylic acid metabolic process	90	9.67	-35.65	-32.14
R-HSA-6798695	Reactome gene sets	Neutrophil degranulation	80	8.59	-34.73	-31.27
ko00020	KEGG pathway	Citrate cycle (TCA cycle)	24	2.58	-30.71	-27.43
GO:0019693	GO biological processes	Ribose phosphate metabolic process	67	7.2	-29.43	-26.19
WP3925	WikiPathways	Amino acid metabolism	35	3.76	-28.63	-25.47
ko00640	KEGG pathway	Propanoate metabolism	22	2.36	-25.68	-22.75
GO:0060627	GO biological processes	Regulation of vesicle-mediated transport	72	7.73	-25.56	-22.66
GO:0032940	GO biological processes	Secretion by cell	87	9.34	-24.09	-21.28
R-HSA-8953897	Reactome gene sets	Cellular responses to stimuli	83	8.92	-22.52	-19.77
R-HSA-422475	Reactome gene sets	Axon guidance	69	7.41	-22.39	-19.66
GO:0010035	GO biological processes	Response to inorganic substance	70	7.52	-22.09	-19.43
GO:0044283	GO biological processes	Small-molecule biosynthetic process	68	7.3	-21.58	-18.95
ko00620	KEGG pathway	Pyruvate metabolism	21	2.26	-21.27	-18.65
WP3888	WikiPathways	VEGFA-VEGFR2 signaling pathway	59	6.34	-20.77	-18.17
GO:0005975	GO biological processes	Carbohydrate metabolic process	69	7.41	-20.62	-18.03
GO:0007005	GO biological processes	Mitochondrion organization	63	6.77	-20.25	-17.66
GO:0051640	GO biological processes	Organelle localization	64	6.87	-20.17	-17.59
ko04721	KEGG pathway	Synaptic vesicle cycle	24	2.58	-19.71	-17.16