Hippocampal Mitochondrial Abnormalities Induced the Dendritic Complexity Reduction and Cognitive Decline in a Rat Model of Spinal Cord Injury

Figure 8

Cognitive impairments after SCI. (a) The latency to platform for 4 consecutive training days in MWM test. There was a significant difference between sham and SCI groups on day 4 (data were presented as , sham, SCI, Student’s unpaired -test, ). (b) The total platform crossings on day 5 of MWM test (data were presented as , sham, SCI, Student’s unpaired -test, ). (c) The search strategy in MWM test (data were presented as constituent ratio, sham, SCI, chi-square test, ). (d) Representative heat map of search strategies. (e-f) Representative heat map in OF test and the proportion of distance travelled in the central zone (%). (Date were presented as , sham, SCI, Student’s unpaired -test, ). (g)–(i) Representative heat map in EPM test, the proportion of distance travelled in open arms (%), and entries in open arms (%) (data were presented as , Sham, SCI, Student’s unpaired -test, , ). (j)–(l) Representative heat map of TCSI test, preference index of “Stranger 1—Empty” and “Stranger 2—Stranger 1.” (data were presented as , sham, SCI, Student’s unpaired -test, ).

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