Ferroptosis-Related Long Noncoding RNAs Have Excellent Predictive Ability for Multiomic Characteristics of Bladder Cancer

Figure 11

Drug sensitivity analysis based on IC50 values. (a) Drug sensitivity analysis of patients with bladder cancer with high or low AC006160.1 expression. The red colour indicates sensitive drugs for samples with high AC006160.1 expression. (b) Compared with patients with low AC006160.1 expression, those with high AC006160.1 expression were more sensitive metformin and methotrexate (). (c) Crystal violet staining of BIU-87 cells transfected with the pcDNA3.1-AC006160.1 or negative control plasmid and subsequently treated with 1-mM metformin for 14 days. (d) CCK-8 assay was performed to examine the proliferation of BIU-87 cells transfected with the pcDNA3.1-AC006160.1 or negative control plasmid and subsequently treated with 1-mM metformin for 72 h. All experiments were performed in triplicate. All data are expressed as the ( versus the control group).

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