Rosin Derivative IDOAMP Inhibits Prostate Cancer Growth via Activating RIPK1/RIPK3/MLKL Signaling Pathway

<div>IDOAMP inhibits Aurora kinase A and promotes RIPK1/RIPK3/MLKL necrosome activation. (a) Inhibition of Aurora kinase A in the presence of IDOAMP after 24 h of incubation. (b) Co-IP analysis of the level of RIPK1 binding to FADD, RIPK3, and MLKL in PC3 cells. (c) Co-IP analysis of the levels of Aurora kinase A binding to RIPK1 and RIPK3 in PC3 cells following treatment with IDOAMP for 24 h. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Rosin Derivative IDOAMP Inhibits Prostate Cancer Growth via Activating RIPK1/RIPK3/MLKL Signaling Pathway 