Current Insights on Bioactive Molecules, Antioxidant, Anti-Inflammatory, and Other Pharmacological Activities of Cinnamomum camphora Linn

Table 6

Unani compound formulations with C. camphora and pharmacological application in preclinical (in vitro/in vivo/in silico) and clinical studies.

Unani formulation	Method/model	Extract use/dosage form	Control/organism tested	Result	Pharmacological application	Ref.
Preclinical studies
Arq-Ajeeb	In vivo (rats)	0.07 ml and 0.14 ml/kg, p.o.	Charcoal administration	Reduce diarrhea in rats	Anti-diarrheal activity	[51]
Compound preparation of sesame oil, camphor, and honey	Animal (rat)	Daily dressing with extract	Oil Vaseline	Maximal healing was noticed in the test group	Healing effect of second-degree burn	[52]
Arq Ajīb contains methanol, camphor	In silico approach	Inhibits SARS-CoV-2 spike glycoprotein and main protease	—	Good interactions and binding affinities with 3CLpro and S glycoprotein	Inhibitory effect on SARS-CoV-2	[53]
Extract C. camphora and Ziziphora tenuior	In vitro mice liver	3, 5, 10, 25, 50, and 100 mg/ml of extracts	—	The extract exhibited dose-dependent and time-dependent antiparasitic effects	Anti-parasitic and immunomodulatory	[54]
Clinical studies
Marham-i-Raal	Single-arm pre- and posttreatment study	2 gm on episiotomy wound	—	REEDA score decreased, and VAS score decreased	Episiotomy wound healing and pain reduction	[55]
Marham-i-Raal	Case study	External application (3 months) (ointment)	—	Completely heal foot ulcer	Chronic wound healing	[21]
Arq Ajib	Clinical study	Liquid application	—	Decrease in VAS score for pain intensity	Headache	[56]
Composition of A. indica and C. camphora	Controlled clinical trial	Oral and topical	Psoralen plus ultraviolet A (PUVA) solution	In individuals with moderate-to-severe CPP, test medications that are efficacious and well-tolerated	Chronic plaque psoriasis	[57]