Inhibition of MicroRNA-182/183 Cluster Ameliorates Schizophrenia by Activating the Axon Guidance Pathway and Upregulating DCC

Figure 3

Inhibition of miR-182/183 cluster improves SZ at different levels: (a) miR-182/183 cluster transfection efficiency (/group); (b) open field test (left), PPI test (middle), and Morris water maze test (right) in SZ rats (/group); (c) representative micrographs showing Nissl body in hippocampal tissues from SZ rats. MK-801-exposed hippocampal neurons were treated with miR-182/183 mimic or AntimiR-182/183; (d) expression of miR-182 and miR-183 in the MK-801-exposed hippocampal neurons determined by RT-qPCR; (e) quantitative analysis of apoptosis of MK-801-exposed hippocampal neurons detected by Hoechst 33342 staining. The data in the figure were measurement data, expressed as the , and analyzed by one-way ANOVA. vs. the AgomiR control or miR-182/183 mimic-NC control; ^#vs. the scrambled control or AgomiR control group. The cell experiments were repeated three times independently.

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