MicroRNA-1224-5p Aggravates Sepsis-Related Acute Lung Injury in Mice

Figure 3

The miR-1224-5p antagomir suppresses oxidative stress in ALI mice. (a) Mice were intravenously injected with the miR-1224-5p antagomir (80 mg/kg/day) or AntagNC for 3 consecutive days and then exposed to LPS (5 mg/kg) for 12 h, and ROS levels in lungs were measured by a DCFH-DA probe. (b) MDA generations in lungs. (c, d) Total SOD activities and GSH content in lungs. (e) Protein levels of NRF2 in lungs. Data represent the ( per group). versus the matched group.

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