MicroRNA-1224-5p Aggravates Sepsis-Related Acute Lung Injury in Mice

Figure 4

The miR-1224-5p antagomir suppresses inflammation in ALI mice. (a) Mice were intravenously injected with the miR-1224-5p antagomir (80 mg/kg/day) or AntagNC for 3 consecutive days and then exposed to LPS (5 mg/kg) for 12 h. BALF was collected and used to measure the cell numbers. (b) MPO activities in lungs. (c, d) The levels of IL-6 and TNF-α in BALF and murine lungs. (e) NF-κB activities in lungs. (f, g) Protein levels of TXNIP, NLRP3 and caspase-1 p10 in lungs. (h) Relative caspase-1 activities in lungs. (i) The levels of IL-1β and IL-18 in murine lungs. Data represent the ( per group). versus the matched group.

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