Fibroblast Growth Factor 19 Improves LPS-Induced Lipid Disorder and Organ Injury by Regulating Metabolomic Characteristics in Mice

Figure 3

PCA scatter plot and OPLS-DA analysis of metabolite profile. Mice were divided into four groups including control, LPS, only FGF19 treatment (FGF19), and pretreatment with FGF19 followed by LPS administration (FGF19 + LPS) (). (a) Score plot with aggregated quality control (QC) samples, (b–d) 2D PCA plot of LPS vs. control group (b), FGF19 + LPS vs. LPS group (c), FGF19 vs. control group (d). (e–h) OPLS-DA score scatter plots and permutation test of OPLS-DA model of LPS vs. control group (e, f) and FGF19 + LPS vs. LPS group (g, h). The abscissa indicates the displacement retention of the permutation test, and the ordinate indicates the value of R2Y or Q2Y. The green dot indicates the R2Y value obtained by the displacement test, the blue square indicates the Q2Y value obtained by the permutation test, and the two dotted lines indicate the regression lines of R2Y and Q2, respectively. The point where the displacement retention is 1 is R2Y and Q2 of the original model.

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