Fibroblast Growth Factor 19 Improves LPS-Induced Lipid Disorder and Organ Injury by Regulating Metabolomic Characteristics in Mice

Figure 4

Differential metabolites (DMs) identified in the multivariate OPLS-DA model and univariate statistical analysis. (a, c) LPS vs. control; (b, d) FGF19 + LPS vs. LPS (). (a, b) Volcano plot representation of DMs. Each point in the map represents one kind of metabolite. Scatter color represents the final screening result, red highlight represents significant upregulation; blue highlight represents significant downregulation, and gray represents nonsignificant DMs. The dataset was screened using VIP value >1 and . (c, d) Heatmaps of DMs. Each column depicts a sample, and each row represents one kind of metabolite. The color of each part corresponds to the concentration value of each metabolite (red, upregulated; blue, downregulated). (e) Venn diagram of the numbers of DMs of LPS vs. control and FGF19 + LPS vs. LPS.

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