Fibroblast Growth Factor 19 Improves LPS-Induced Lipid Disorder and Organ Injury by Regulating Metabolomic Characteristics in Mice

Figure 8

FGF19 improves LPS-induced oxidative stress. Mice were divided into four groups including Control, LPS, only FGF19 treatment (FGF19), and pretreatment with FGF19 followed by LPS administration (FGF19+LPS) (). (a) Serum levels of MDA and CAT. (b) The mRNA level of Sod1, Sod2, Gpx1, Cat, iNos, Nrf2, and Ho-1 in the livers. (c) Immunohistochemical staining against iNOS in the livers. Scale bars, 200 μm. (d) Immunofluorescent staining against HO-1 (green) in livers and DAPI (blue) was used to highlight the cell nucleus (40×). (e) NRF2 protein levels in the livers. (f) HO-1 protein levels in the livers. All data are presented as . indicates the significant difference compared with control group, ^& indicates the significant difference compared with FGF19 group, ^# indicates the significant difference compared with LPS group.

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