Adaptation of the Oxygen Sensing System during Lung Development

Figure 3

scRNA-seq analysis for cell type and average expression of HIF-PHD system genes in the mouse lung. (a) Cluster allocation for epithelial (9.5%), endothelial (30.7%), and mesenchymal (59.8%) lung cell types in the UMAP (Uniform Manifold Approximation and Projection) plot from integrated scRNA-seq datasets from all selected time points of the developing lung. Each color represents a cellular subtype as specified in the respective legend. (b) Average relative expression of the HIF-PHD system genes in each cell type, combined from all time points. EC: endothelial cell; AT1/2: alveolar type 1/2 cell; FB: fibroblast.

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