Research Article
Adaptation of the Oxygen Sensing System during Lung Development
Figure 8
Effects of systemic hypoxia or roxadustat treatment on HRG expression in vivo. (a, c) Absolute expression quantification of bona fide HRGs in adult mice exposed to 21% vs. 8% O2 for 8 h or treated with vehicle or roxadustat for 8 h, respectively. Statistically significant induction (Mann-Whitney test; systemic hypoxia: per condition, roxadustat: per condition) in comparison to the respective controls is indicated by and , repression by §. The black bars represent the medians. (b, d) HIF (de)stabilization was confirmed by immunoblotting. β-Actin served as a loading control.
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