Dapagliflozin Ameliorates Renal Tubular Ferroptosis in Diabetes via SLC40A1 Stabilization

Figure 6

The potential mechanism of dapagliflozin stabilizes SLC40A1 of the renal tubule in diabetes. (a) The ubiquitination of SLC40A1, assessed by western blot analysis following immunoprecipitation. (b) Frontal view of the 3D model of the binding of dapagliflozin to the SLC40A1 complex. (c) Stereoview of the binding mode of dapagliflozin in its complex with SLC40A1, in which the H-bonds are depicted as yellow dotted lines. (d) Specific view of the 2D ligand interaction of dapagliflozin with SLC40A1. (e) Schematic representation of the pathways involved in DKD through the dapagliflozin-regulated SLC40A1/ferroptosis pathway.

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