Four-Octyl Itaconate Attenuates UVB-Induced Melanocytes and Keratinocytes Apoptosis by Nrf2 Activation-Dependent ROS Inhibition

<div>A proposed mechanism of the protective effect of 4-OI in UVB-induced skin cell damage. UVB causes HaCaT and PIG1 cell apoptosis via ROS production. 4-OI promotes Nrf2 nuclear translocation, activates the Nrf2/HO-1 signaling pathway, subsequently inhibits ROS generation, and then alleviates cell apoptosis.</div>

Oxidative Medicine and Cellular Longevity

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Figure 6

Figure 6: Four-Octyl Itaconate Attenuates UVB-Induced Melanocytes and Keratinocytes Apoptosis by Nrf2 Activation-Dependent ROS Inhibition 