Research Article
Forsythiaside A Regulates Activation of Hepatic Stellate Cells by Inhibiting NOX4-Dependent ROS
Figure 7
FA inhibited the TGF-β1-induced activation of NOX4/ROS and PI3K/Akt pathway. (A-B) The expression of NOX4 and p22phox mRNA. (C-D) The expression of NOX4 and p22phox proteins. (E-F) The phosphorylation levels of PI3K and Akt. Data of three independent experiments were represented by mean ± S.D. p <0.001 TGF-β1 vs control; p <0.05 TGF-β1 vs control. ###p <0.001 TGF-β1 + FA vs TGF-β1;##p <0.01 TGF-β1 + FA vs TGF-β1.
(a) |
(b) |
(c) |
(d) |
(e) |
(f) |