Transdermal Administration of Volatile Oil from Citrus aurantium-Rhizoma Atractylodis Macrocephalae Alleviates Constipation in Rats by Altering Host Metabolome and Intestinal Microbiota Composition

Figure 1

Effect of ZBVO on improving the fecal water content and intestinal transit rate of STC rats induced by compound diphenoxylate tablets (). (a) Schematic diagram of STC model establishment and transdermal drug administration treatment. (b) ZBVO improved intestinal propulsion rate and intestinal transit in diphenoxylate-induced STC rats (150, 300, and 600 μL kg^-1 d^-1) and mosapride. (c) Compared with the MC group, ZBVO dosing (150, 300, and 600 μL kg^-1 d^-1) increased fecal water content in rats. Values are expressed as . , , and vs. the BC group. ^#, ^##, and ^### vs. the MC group.

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