Transdermal Administration of Volatile Oil from Citrus aurantium-Rhizoma Atractylodis Macrocephalae Alleviates Constipation in Rats by Altering Host Metabolome and Intestinal Microbiota Composition
Table 3
Differential metabolites in rat feces after administration ().
Name
Formula
Detected
VIP value (MD/MC)
VIP value (HD/MC)
HMDB ID
KEGG
Uridine
C9H12N2O6
243.0648
1.54 ↑#
—
HMDB0000296
C00299
Glycochenodeoxycholate
C26H43NO5
432.3012
1.47 ↑#
—
HMDB0000637
C05466
Arachidonic acid (peroxide-free)
C20H32O2
269.2062
1.54 ↑#
—
HMDB0001043
C00219
Quinolinate
C7H5NO4
166.0165
1.69 ↑##
1.75 ↑##
HMDB0000232
C03722
1-Methylnicotinamide
C7H9N2O
138.0576
1.45 ↑#
—
HMDB0000699
C02918
Xanthosine
C10H12N4O6
285.0836
1.48 ↑#
1.91 ↑##
HMDB0000299
C01762
3-Phenylpropanoic acid
C9H10O2
149.0622
1.81 ↓##
—
HMDB0000764
C05629
Azelaic acid
C9H16O4
187.0997
1.78 ↓##
—
HMDB0000784
C08261
L-Malic acid
C4H6O5
133.0146
—
1.79 ↑##
HMDB0000156
C00149
Deoxyadenosine
C10H13N5O3
252.1042
—
1.48 ↓#
HMDB0000101
C00559
Note: “↓” or “↑” compared with the model control group, the metabolites in the middle-dose (MD) group and the high-dose (HD) group decreased or increased significantly.