Investigation of the Effects of Glabridin on the Proliferation, Apoptosis, and Migration of the Human Colon Cancer Cell Lines SW480 and SW620 and Its Mechanism Based on Reverse Virtual Screening and Proteomics

Figure 6

(a) GBN vs. c_SW620 differential protein KEGG enrichment analysis diagram; (b) GBN vs. c_SW480 differential protein KEGG enrichment analysis diagram. Note: (1) In the column chart, the abscissa represents the pathway name, and the ordinate represented the enrichment rate (the greater the ratio, the greater the degree of enrichment). (2) The color gradient of the column indicated the significance of enrichment, and the darker the color indicated the higher the enrichment degree of the KEGG term (, , and ). The enriched string diagram showed the corresponding relationship between the target protein and the KEGG pathway. The left side was the protein, and the order from top to bottom showed . The greater the , the difference in the expression of the upregulated protein was the greater. On the right was the KEGG pathway name and score of the target protein. On the right was the KEGG pathway name and score of the target protein. Among them, count represented the total number of target proteins involved in this pathway. Up represented the number of upregulated proteins involved in this pathway. Down represented the number of downregulated proteins involved in this pathway. If score was greater than zero, it meant that there were more upregulated proteins than downregulated proteins involved in this pathway, and this pathway was more likely to be activated. Conversely, score was less than zero, which meant that this pathway is more likely to be inhibited.

(a)

(b)