Investigation of the Effects of Glabridin on the Proliferation, Apoptosis, and Migration of the Human Colon Cancer Cell Lines SW480 and SW620 and Its Mechanism Based on Reverse Virtual Screening and Proteomics

Table 4

Potential target proteins related to the signaling pathways involved in GBN.

Gene symbol	Uniprot_AC	Gene_ID	Target name	Score	PDB_pocket	Pathway
CDK2	P24941	1017	Cyclin-dependent kinase 2	-12.9	1jvp_P_LIG_301	PI3K/AKT, p53
HSP90AA1	P07900	3320	Heat shock protein HSP 90-alpha	-12	3d0b_A_SNX_233	PI3K/AKT
ABL1	P00519	25	Tyrosine-protein kinase ABL1	-11.5	2hyy_C_STI_600	ErbB
INS	P01308	3630	Insulin preproprotein	-11	2om1_e_RCO_1014	PI3K/AKT, mTOR, MAPK
MAPK14	Q16539	1432	Mitogen-activated protein kinase 14	-11	2zb1_A_GK4_361	MAPK
CSNK2A1	P68400	1457	Casein kinase II subunit alpha	-10.8	3r0t_A_FU9_338	Wnt
PPARD	Q03181	5467	Peroxisome proliferator-activated receptor delta	-10.6	1gwx_A_433_1	Wnt
PRKACA	P17612	5566	cAMP-dependent protein kinase catalytic subunit alpha isoform 1	-10.5	3l9l_B_L9L_351	Wnt, MAPK, hedgehog
EIF4E	P06730	1977	Eukaryotic translation initiation factor 4E	-10.5	4aza_A_MGO_1218	PI3K/AKT, mTOR
HSP90AB1	P08238	3326	Heat shock protein HSP 90-beta	-10.5	1uym_A_PU3_1224	PI3K/AKT
SRC	P12931	6714	Proto-oncogene tyrosine-proteinkinase Src	-10.4	2h8h_A_H8H_534	ErbB
IRAK4	Q9NWZ3	51135	Interleukin-1 receptor-associated kinase 4	-10.4	2nry_D_STU_501	MAPK
RXRA	P19793	6256	Retinoic acid receptor RXR-alpha	-10.3	1g5y_B_REA_501	PI3K/AKT
CHEK1	O14757	1111	Serine/threonine-protein kinase Chk1	-10.3	2e9n_A_76A_1001	p53
KDR	P35968	3791	Vascular endothelial growth factor receptor 2	-10.2	3vhe_A_42Q_1170	PI3K/AKT, MAPK
TGFBR1	P36897	7046	TGF-beta receptor type-1	-10.2	1py5_A_PY1_700	TGF-β, MAPK
MAPK10	P53779	5602	Mitogen-activated protein kinase 10	-10.1	2waj_A_SNB_1401	Wnt, MAPK, ErbB
BRAF	P15056	673	Serine/threonine-protein kinase B-raf	-10.1	4h58_A_10Z_801	ErbB, mTOR, MAPK