Long Noncoding RNA LINC00578 Inhibits Ferroptosis in Pancreatic Cancer via Regulating SLC7A11 Ubiquitination

Figure 1

LINC00578 is upregulated in pancreatic cancer and correlated with clinicopathological factors. (a) Box plot of LINC00578 expression in 34 kinds of cancers from the TCGA (PANCAN, , ) cohort. (b) Box plot of LINC00578 expression in both pancreatic cancer tissues () and normal tissues () from the TCGA-GTEx cohort. (c) Box plot of LINC00578 expression in pancreatic cancer tissues () and adjacent normal tissues () from the Su cohort. (d) The expression ratio of LINC00578 between tumors and adjacent normal tissues from the Su cohort. (e) The expression of LINC00578 between T1/T2 and T3/T4 stages from the Su cohort. (f) The expression of LINC00578 between N0 and N1/N2 stages from the Su cohort. (g) The expression of LINC00578 between Grade I and Grade II from the Su cohort. (h) Kaplan–Meier curve showing the correlation of the LINC00578 expression with overall survival (OS) () in the TCGA cohort. ; ; ; . Abbreviations: ACC: adrenocortical carcinoma; ALL: acute lymphoblastic leukemia; BLCA: bladder urothelial carcinoma; CESC: cervical squamous cell carcinoma and endocervical adenocarcinoma; COAD: colon adenocarcinoma; COADREAD: colon adenocarcinoma/rectum adenocarcinoma; CHOL: cholangiocarcinoma; ESCA: esophageal carcinoma; GBM: glioblastoma multiforme; GBMLGG: glioma; HNSC: head and neck squamous cell carcinoma; KICH: kidney chromophobe; KIRC: kidney renal clear cell carcinoma; KIRP: kidney renal papillary cell carcinoma; KIPAN: pankidney cohort (KICH+KIRC+KIRP); LAML: acute myeloid leukemia; LGG: brain lower grade glioma; LIHC: liver hepatocellular carcinoma; LUAD: lung adenocarcinoma; LUSC: lung squamous cell carcinoma; OV: ovarian serous cystadenocarcinoma; PAAD: pancreatic adenocarcinoma; PCPG: pheochromocytoma and paraganglioma; PRAD: prostate adenocarcinoma; READ: rectum adenocarcinoma; STAD: stomach adenocarcinoma; STES: stomach and esophageal carcinoma; SKCM: skin cutaneous melanoma; THCA: thyroid carcinoma; TGCT: testicular germ cell tumors; UCEC: uterine corpus endometrial carcinoma; UCS: uterine carcinosarcoma; WT: high-risk Wilms tumor.

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