Combination Therapy with Indigo and Indirubin for Ulcerative Colitis via Reinforcing Intestinal Barrier Function

Figure 1

INB and IND alleviated the inflammatory injury of DSS-induced colitis. (a) DSS-induced UC mice were orally administrated with INB (20 mg/kg), IND (20 mg/kg), and INB+IND (20 mg/kg), and the normal mice were given normal drinking water throughout the experiment. (b) Body weight change (% initial body weight) and disease activity index (DAI) of mice, . (c) Representative images of colon morphology and statistics of colon length, . (d–i) Cytokine secretion in colon tissue, . (j) Representative images of bioluminescent imaging and ROS/RNS signals after administration of L-012, . (k) Representative images of H&E staining of proximal colon and histological scores. and compared with the DSS group; ^# and ^## compared with the INB+IND group, .

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