Oxidative Medicine and Cellular Longevity / 2023 / Article / Tab 3 / Research Article
Metabolomics Profiling of Age-Associated Metabolites in Malay Population Table 3 Metabolites associated with age.
Compound name Agea Malesb Femalesc value value valuePositively associated with age 3-Methoxybenzenepropanoic acid 0.32 2.2 - 11 0.27 3.8 - 4 0.35 6.1 - 9 4-Methylphenol — — 0.26 6.2 - 4 — — 4-Oxoproline 0.16 8.0 - 4 — — 0.22 3.4 - 4 Aconitic acid (cis/trans) 0.14 3.7 - 3 — — — — Caprolactam 0.14 3.4 - 3 — — 0.25 3.6 - 5 Citrulline 0.25 2.7 - 7 0.24 2.1 - 3 0.25 3.6 - 5 Deoxycholic acid 0.12 1.7 - 2 0.29 1.1 - 4 — — Docosahexaenoic acid ethyl ester (DHAEE) — — 0.28 2.5 - 4 — — Erucamide 0.32 1.2 - 11 0.22 3.9 - 3 0.38 7.4 - 11 Glutamine 0.19 9.9 - 5 0.23 2.3 - 3 0.16 8.1 - 3 Hippuric acid 0.17 4.8 - 4 — — — — N-Acetylornithine 0.27 2.2 - 8 0.20 9.1 - 3 0.31 1.6 - 7 N-Phenylacetylglutamine 0.23 2.0 - 6 0.36 2.0 - 6 — — Pro Phe Arg 0.15 2.4 - 3 — — 0.20 9.1 - 4 Theophylline 0.15 2.4 - 3 0.19 1.2 - 2 — — Negatively associated with age 11-Deoxy prostaglandin F2β -0.21 4.4 - 5 -0.27 6.9 - 4 -0.16 1.0 - 2 12-Hydroxy-10-(hydroxymethyl)-6-methyl-2-(4-methyl-3-penten-1-yl)-2,6,10-dodecatrienoic acid -0.19 8.6 - 5 -0.25 9.4 - 4 -0.16 1.0 - 2 13,14-Dihydro-15-keto prostaglandin A2 — — -0.21 6.7 - 3 — — 9(E),11(E)-Conjugated linoleic acid -0.19 7.1 - 5 -0.28 2.6 - 4 — — Cortisol -0.20 3.6 - 5 — — -0.23 1.1 - 4 Glycoursodeoxycholic acid — — — — -0.18 3.1 - 3 Guanosine monophosphate -0.24 9.1 - 7 -0.32 2.2 - 5 -0.17 4.1 - 3 Isoquinoline -0.12 1.5 - 2 — — — — Leu Tyr -0.21 2.1 - 5 -0.29 1.6 - 4 -0.15 1.2 - 2 N-Acetyl-L-carnosine -0.11 1.8 - 2 — — — — Nicotinamide -0.20 3.9 - 5 -0.28 2.2 - 4 — — Phenylalanine -0.12 1.5 - 2 — — — — Proline -0.14 4.0 - 3 -0.24 1.9 - 3 — — Testosterone sulfate -0.57 1.3 - 38 -0.60 6.3 - 18 -0.54 6.6 - 22 Tryptophan — — — — -0.15 1.3 - 2 Uracil -0.20 3.3 - 5 -0.37 1.0 - 6 — —
a Age-associated metabolites adjusted for gender;
: unstandardized coefficients;
b age-associated metabolites in males;
c age-associated metabolites in females;
detected in both modes, values shown for positive mode; compounds were sorted according to alphanumerical order.