Metabolomics Profiling of Age-Associated Metabolites in Malay Population

Table 3

Metabolites associated with age.

Compound name	Age^a		Males^b		Females^c
		value		value		value
Positively associated with age
3-Methoxybenzenepropanoic acid	0.32	2.2-11	0.27	3.8-4	0.35	6.1-9
4-Methylphenol	—	—	0.26	6.2-4	—	—
4-Oxoproline	0.16	8.0-4	—	—	0.22	3.4-4
Aconitic acid (cis/trans)	0.14	3.7-3	—	—	—	—
Caprolactam	0.14	3.4-3	—	—	0.25	3.6-5
Citrulline	0.25	2.7-7	0.24	2.1-3	0.25	3.6-5
Deoxycholic acid	0.12	1.7-2	0.29	1.1-4	—	—
Docosahexaenoic acid ethyl ester (DHAEE)	—	—	0.28	2.5-4	—	—
Erucamide	0.32	1.2-11	0.22	3.9-3	0.38	7.4-11
Glutamine	0.19	9.9-5	0.23	2.3-3	0.16	8.1-3
Hippuric acid	0.17	4.8-4	—	—	—	—
N-Acetylornithine	0.27	2.2-8	0.20	9.1-3	0.31	1.6-7
N-Phenylacetylglutamine	0.23	2.0-6	0.36	2.0-6	—	—
Pro Phe Arg	0.15	2.4-3	—	—	0.20	9.1-4
Theophylline	0.15	2.4-3	0.19	1.2-2	—	—
Negatively associated with age
11-Deoxy prostaglandin F2β	-0.21	4.4-5	-0.27	6.9-4	-0.16	1.0-2
12-Hydroxy-10-(hydroxymethyl)-6-methyl-2-(4-methyl-3-penten-1-yl)-2,6,10-dodecatrienoic acid	-0.19	8.6-5	-0.25	9.4-4	-0.16	1.0-2
13,14-Dihydro-15-keto prostaglandin A2	—	—	-0.21	6.7-3	—	—
9(E),11(E)-Conjugated linoleic acid	-0.19	7.1-5	-0.28	2.6-4	—	—
Cortisol	-0.20	3.6-5	—	—	-0.23	1.1-4
Glycoursodeoxycholic acid	—	—	—	—	-0.18	3.1-3
Guanosine monophosphate	-0.24	9.1-7	-0.32	2.2-5	-0.17	4.1-3
Isoquinoline	-0.12	1.5-2	—	—	—	—
Leu Tyr	-0.21	2.1-5	-0.29	1.6-4	-0.15	1.2-2
N-Acetyl-L-carnosine	-0.11	1.8-2	—	—	—	—
Nicotinamide	-0.20	3.9-5	-0.28	2.2-4	—	—
Phenylalanine	-0.12	1.5-2	—	—	—	—
Proline	-0.14	4.0-3	-0.24	1.9-3	—	—
Testosterone sulfate	-0.57	1.3-38	-0.60	6.3-18	-0.54	6.6-22
Tryptophan	—	—	—	—	-0.15	1.3-2
Uracil	-0.20	3.3-5	-0.37	1.0-6	—	—

^aAge-associated metabolites adjusted for gender; : unstandardized coefficients; ^bage-associated metabolites in males; ^cage-associated metabolites in females; detected in both modes, values shown for positive mode; compounds were sorted according to alphanumerical order.