Epiisopiloturine, an Alkaloid from Pilocarpus microphyllus, Attenuates LPS-Induced Neuroinflammation by Interfering in the TLR4/NF-κB-MAPK Signaling Pathway in Microglial Cells

Figure 6

Effect of EPI on TLR4 (a), NF-κB (b), JNK (c), and ERK1/2 (d). BV-2 cells were pretreated with EPI (25 μg/mL) for 1 h, followed by LPS (0.5 μg/mL) for 1 hour. Results are expressed as . # vs. vehicle/RPMI; vs. vehicle group stimulated with LPS (—two-way ANOVA and Bonferroni test), .

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