Epiisopiloturine, an Alkaloid from <i>Pilocarpus microphyllus</i>, Attenuates LPS-Induced Neuroinflammation by Interfering in the TLR4/NF-<i>κ</i>B-MAPK Signaling Pathway in Microglial Cells

<div>Anti-inflammatory effects mediated by the alkaloid epiisopiloturine (EPI) in microglia. EPI inhibits TLR4 expression and phosphorylation of NF-<i>κ</i>B p65 and MAPKs (JNK and ERK1/2) induced by LPS.</div>

Oxidative Medicine and Cellular Longevity

fig8

Figure 8

Figure 8: Epiisopiloturine, an Alkaloid from <i>Pilocarpus microphyllus</i>, Attenuates LPS-Induced Neuroinflammation by Interfering in the TLR4/NF-<i>κ</i>B-MAPK Signaling Pathway in Microglial Cells 

Figure 8 | Epiisopiloturine, an Alkaloid from Pilocarpus microphyllus, Attenuates LPS-Induced Neuroinflammation by Interfering in the TLR4/NF-κB-MAPK Signaling Pathway in Microglial Cells 