Overexpression of PRDX2 in Adipose-Derived Mesenchymal Stem Cells Enhances the Therapeutic Effect in a Neurogenic Erectile Dysfunction Rat Model by Inhibiting Ferroptosis

Figure 5

PRDX2-ADSC treatment prevented fibrosis of the corpus cavernosum and increased cavernosal smooth muscle content. (a, b) Immunofluorescent staining of SMA of corpus cavernosum in the sham, PBS, vehicle, and ADSC-P groups ( per group). (c, d) SMA protein expression of corpus cavernosum in the sham, PBS, vehicle, and ADSC-P groups determined by western blotting analysis ( per group). (e, f) Smooth muscle to collagen ratio in the corpus cavernosum assessed by Masson’s trichrome staining in the sham, PBS, vehicle-ADSCs, and ADSC-P groups ( per group). Vehicle, group injected with vehicle-ADSCs. ADSC-P, group injected with PRDX2-ADSCs. , , , and .

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