Overexpression of PRDX2 in Adipose-Derived Mesenchymal Stem Cells Enhances the Therapeutic Effect in a Neurogenic Erectile Dysfunction Rat Model by Inhibiting Ferroptosis

Figure 6

PRDX2-ADSC therapy prevented oxidative stress and ferroptosis injury in the corpus cavernosum. (a, b) Superoxide anion production was detected by fluorescence analysis ( per group). (c, d) Mitochondrial superoxide levels were detected by fluorescence analysis ( per group). (e-h) The levels of total iron content, MDA, SOD, and GSH in corpus cavernosum were measured ( per group). (i–k) Representative western blot results and quantification of GPX4 and ACSL4 in corpus cavernosum ( per group). Vehicle, group injected with vehicle-ADSCs. ADSC-P, group injected with PRDX2-ADSCs. , , and . MFI: mean fluorescence intensity.

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