α-Synuclein Attenuates Maneb Neurotoxicity through the Modulation of Redox-Sensitive Transcription Factors

Figure 8

SIRT1 is involved in the antioxidant response in cells overexpressing α-synuclein upon MB injury. (a) SIRT1 localization and expression were assessed by immunocytochemistry studies in control and wt α-syn cells upon MB treatment. (b, c) After TSA (200 nM) treatment, GSH synthesis and lipid peroxidation were determined in cells with endogenous expression and overexpressing α-synuclein exposed to the pesticide. (a–c) Results are expressed as arbitrary units and represent (-4). (a–c) , , and for each condition with respect to the control; one-way ANOVA and Tukey’s post hoc test.

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