Ferroptosis in Rat Lung Tissue during Severe Acute Pancreatitis-Associated Acute Lung Injury: Protection of Qingyi Decoction

Figure 2

Determination of core targets of QYD against SAP-associated ALI. (a) Volcano plot showing DEPs between the SAP and CON groups. (b) Volcano plot showing DEPs between the QYD and SAP groups. (c) GO enrichment analysis of 202 overlapped DEGs in the term of biological process. (d) Pathway annotation of 202 overlapped DEGs by KEGG terms. (e) Venn diagram between the 202 overlapped DEGs and the 514 drug targets of QYD. The integrated analysis of proteomic data and network pharmacology results yielded three core targets of QYD for SAP-associated ALI: ALDH2, AnxA1, and ICAM-1. (f) Construction of a drug-active ingredient-target network based on the three core targets obtained. Yellow dots represented each herb of QYD; purple dots represented the active ingredients of QYD; red dots represented the target proteins.

(a)

(b)

(c)

(d)

(e)

(f)